Sodium oxybate (SXB), first developed in the 1960s, is a central nervous system depressant recommended by the American Academy of Sleep Medicine, European guidelines, and expert statements for the treatment …
A rare genetic variant in the cleavage site of prepro-orexin is associated with idiopathic hypersomnia
Idiopathic hypersomnia (IH) is a rare heterogeneous disorder characterized by prolonged and disabling excessive daytime sleepiness (intolerable sleepiness in the daytime)1. Patients with narcolepsy type 1, which is a well-recognized …
Treatment of Kleine-Levin Syndrome With Intranasal Photobiomodulation and Methylene Blue
Kleine-Levin syndrome (KLS) is a rare neurological disorder characterized by recurrent episodes of hypersomnia, coupled with behavioral and cognitive abnormalities [1]. Cognitive abnormalities will include derealization and may involve memory …
Stability of nocturnal wake and sleep stages defines central nervous system disorders of hypersomnolence
Central nervous system (CNS) disorders of hypersomnolence are characterized by excessive daytime sleepiness despite sufficient nocturnal sleep. The most common of these disorders typically begin in the first two decades …
Parthenogenetic mosaicism: generation via second polar body retention and unmasking of a likely causative PER2 variant for hypersomnia
Normal mammalian development requires both maternal and paternal genomes, because of the presence of multiple imprinted genes [1]. Thus, parthenogenetic mammals are incompatible with life because of absent expression of …
Multiple sleep latency test and polysomnography in patients with central disorders of hypersomnolence
A multiple sleep latency test (MSLT) with occurrence of sleep onset REM periods (SOREMP) is considered one of the central diagnostic criteria for narcolepsy according to the International Classification of …
Sleep Neurology’s Toolkit at the Crossroads: Challenges and Opportunities in Neurotherapeutics Lost and Found in Translation
We find ourselves at our present crossroads with a well-traveled toolkit, perhaps too well worn but with aspirational hopes and dreams for the field of sleep neurotherapeutics. This volume is …
Parthenogenetic mosaicism: generation via second polar body retention and unmasking of a likely causative PER2 variant for hypersomnia
Background: Parthenogenetic mosaicism is an extremely rare condition identified only in five subjects to date. The previous studies indicate that this condition is mediated by parthenogenetic activation and is free from …
European guideline and expert statements on the management of narcolepsy in adults and children
Background and aim: Narcolepsy is an uncommon hypothalamic disorder of presumed autoimmune origin that usually requires lifelong treatment. This paper aims to provide evidence-based guidelines for the management of narcolepsy …
Cognitive Behavioral Therapy for Insomnia has sustained effects on insomnia, fatigue, and function among people with chronic heart failure and insomnia: The HeartSleep Study
Study objectives: Insomnia is common among adults with chronic heart failure (HF) and associated with daytime symptoms and decrements in function. The purpose of this randomized controlled trial (RCT) was to …
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