5.5-fold increased odds of insomnia symptoms worsening into adult insomnia for short-sleeping adolescents THURSDAY, Feb. 17, 2022 (HealthDay News) — For children with insomnia symptoms, 43.3 percent have a persistent …
Stability of nocturnal wake and sleep stages defines central nervous system disorders of hypersomnolence
Central nervous system (CNS) disorders of hypersomnolence are characterized by excessive daytime sleepiness despite sufficient nocturnal sleep. The most common of these disorders typically begin in the first two decades …
Parthenogenetic mosaicism: generation via second polar body retention and unmasking of a likely causative PER2 variant for hypersomnia
Normal mammalian development requires both maternal and paternal genomes, because of the presence of multiple imprinted genes [1]. Thus, parthenogenetic mammals are incompatible with life because of absent expression of …
A Systematic Review and Individual Participant Data Level Meta-Analysis of Primary vs. Specialist Care for Obstructive Sleep Apnea
Primary care providers may be ideally positioned to have a larger role in treating obstructive sleep apnea. Objectives: Using an individual-participant data meta-analysis, establish whether age, gender, the severity of …
The Development of Sleep/Wake Disruption and Cataplexy as Hypocretin/Orexin Neurons Degenerate in Male vs. Female Orexin/tTA; TetO-DTA Mice
Narcolepsy Type 1 (NT1), a sleep disorder with similar prevalence in both sexes, is thought to be due to loss of the hypocretin/orexin (Hcrt) neurons. Several transgenic strains have been …