5.5-fold increased odds of insomnia symptoms worsening into adult insomnia for short-sleeping adolescents THURSDAY, Feb. 17, 2022 (HealthDay News) — For children with insomnia symptoms, 43.3 percent have a persistent …
Stability of nocturnal wake and sleep stages defines central nervous system disorders of hypersomnolence
Central nervous system (CNS) disorders of hypersomnolence are characterized by excessive daytime sleepiness despite sufficient nocturnal sleep. The most common of these disorders typically begin in the first two decades …
Parthenogenetic mosaicism: generation via second polar body retention and unmasking of a likely causative PER2 variant for hypersomnia
Normal mammalian development requires both maternal and paternal genomes, because of the presence of multiple imprinted genes [1]. Thus, parthenogenetic mammals are incompatible with life because of absent expression of …
A Systematic Review and Individual Participant Data Level Meta-Analysis of Primary vs. Specialist Care for Obstructive Sleep Apnea
Primary care providers may be ideally positioned to have a larger role in treating obstructive sleep apnea. Objectives: Using an individual-participant data meta-analysis, establish whether age, gender, the severity of …
The Development of Sleep/Wake Disruption and Cataplexy as Hypocretin/Orexin Neurons Degenerate in Male vs. Female Orexin/tTA; TetO-DTA Mice
Narcolepsy Type 1 (NT1), a sleep disorder with similar prevalence in both sexes, is thought to be due to loss of the hypocretin/orexin (Hcrt) neurons. Several transgenic strains have been …
Daridorexant Improves Sleep Outcomes for Adults With Insomnia
Daridorexant, a dual orexin receptor antagonist approved by the FDA in January 2022 for insomnia disorders, improved sleep outcomes at doses of 25 mg or 50 mg with a favorable safety profile, …
Rosacea, poor sleep quality and obstructive sleep apnea: a commentary on potential interconnected features
Although rosacea is classically considered a skin disorder, recent evidence shows that it is emerging as a systemic vascular disease. The classical symptoms of burning, intense erythema and flushing could …
Efficacy and Acceptability of Intermittent Aerobic Exercise on Polysomnography-Measured Sleep in People With Rheumatoid Arthritis With Self-Reported Sleep Disturbance: A Randomized Controlled Trial
This study’s objective was to investigate the efficacy and acceptability of intermittent aerobic exercise training on sleep parameters, fatigue, pain, depressive symptoms, physical function, and cardiorespiratory fitness in people with …
Effect of sleep surgery on blood pressure in adults with obstructive sleep apnea: A Systematic Review and meta-analysis
This meta-analysis evaluates the effect of sleep surgery on blood pressure (BP) in adults with OSA. The study protocol was registered on PROSPERO (CRD42020154425). The PubMed, MEDLINE, EMBASE, and Cochrane …